Genomic medicine stems from Mendel’s seminal work on heredity and the completion of the Human Genome Project in 2003. Genomics is the study of functions and interactions of all the genes in the genome, not just of single genes as in genetics. With the advent of microarray technologies and next generation sequencing and their powerful application in genomewide association studies, genomic medicine has become now an even more essential part of medicine, and in particular, personalized and precision medicine. Currently, there is considerable controversy around neonatal genomic sequencing and its bioethical implications.
- Aspinall MG et al. Realizing the Promise of Personalized Medicine. Harv Bus Rev 2007; 85(10): 108-117.
- Feero WG et al. Review Article: Genomic Medicine- An Updated Primer. N Engl J Med 2010; 362: 2001-11.
- Guttmacher AE et al. Review Article: Genomic Medicine. N Engl J Med 2002; 347: 1512-1520.
- Hudson KL. Review Article: Genomics, Health Care, and Society. N Engl J Med 2011; 365: 1033-1041.
- Manolio TA. Genomewide Association Studies and Assessment of the Risk of Disease. N Engl J Med 2010; 363: 166-176.