Dr. Cooper is assuming the role of Chair of the UCI Department of Pediatrics (effective August 2011) and is PI of the UCI Institute for Clinical and Translational Science. He is an NIH funded nationally known child health researcher; has trained more than 35 pediatrician-scientists and PhDs, and led UCIs efforts first to create its first General Clinical Research Center and subsequently its successful application for a CTSA in 2009. Dr. Cooper is active in the CHOC Pediatric Pulmonary Clinic and is Board-Certified in Pediatrics and in Pediatric Pulmonology. Dr. Cooper’s role as PI of the UCI CTSA provides distinct advantages to the planned SoCal DRC. First, Dr. Cooper is privy to and involved in the latest profound changes in the NIH associated with NIH Director Dr. Francis Collins’ new vision for the link between basic science and therapeutic applications embodied in his plans for the National Center for the Advancement of Translational Science (NCATS). Second, Dr. Cooper is an active, standing member of the CTSA Consortium Key Function Committee–Child Health Oversight Committee (CC-CHOC). Representing all 60 CTSAs, CC-CHOC has developed a robust vision for pediatric research that emphasizes the need to improve the training of the next generation of pediatric health care researchers. From 1995 through 1999, Dr. Cooper was a member of the Respiratory and Applied Physiology NIH Study Section and serves regularly as an ad hoc member of several NIH study sections. His research group has focused on the mechanisms that link physical activity with the process of growth and development in healthy children and in children with disease and disability. The context of this research is uniquely suited to the goals of translational science imbedded in this DRC proposal. His group is actively investigating the molecular mechanisms that govern the inflammatory genomic and epigenetic response to exercise in leukocytes; has created the first animal model of exercise-induced bronchoconstriction; and he recently led the UCI site of the seven-center NIDDK Project HEALTHY. HEALTHY tested a school-based intervention program designed to enhance physical activity, nutrition, and health behaviors to prevent obesity and risk for type 2 diabetes in lower SES, predominately minority schools at seven sites throughout the country. The results of this study were recently published in the New England Journal of Medicine.